Molecular Drug Targets in Candida glabrata
Keywords:
Candida glabrata, Molecular Target, Drug Target, Kre1, Kre2, Cch1, Mid1, Cdr1, Rox1, Upc2B.Abstract
Incidence of candidiasis has increased in past decade. Epidemiology is reported shifting from albicans to non-
albicans Candida (NAC) species like C. glabrata, which is intrinsically resistant to azole drugs. No new
antifungal has come into practice from last decade. Rising resistance to existing antifungal (in clinical isolates of
Candida) have necessitated the need for new antifungals. New molecular drug targets need to be explored for
the development of novel antifungal drugs. The drug targets are oftenly the cellular proteins of various
metabolic pathways (like ergosterol synthesis-, cell wall biogenesis-, calcium-calcineurin- and DNA checkpoint
pathways etc.), having no significant similarity with host proteins to overrule the possibility of side effects. In
this review, some potential proteins of C. glabrata and their pathways are discussed in context to explore their
potential as drug target for antifungal drug development.
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