AFM study on amyloid peptide - graphene oxide assembly and its interaction with liposome
Abstract
The interaction between amyloid peptides and membrane is a broad
research topic due to the variety of biological events occurring, such as the membrane
disruption related pathogenesis of amyloid diseases or the toxicity of peptide
materials. Amyloid peptides have many structural forms, it is therefore important to
explore the interactions between the membrane and assemblies of amyloid peptides,
and to find ways to control these interactions. Herein, we utilized atomic force
microscopy (AFM) and circular dichroism spectra to explore the modulating effect of
Graphene Oxide (GO) on amyloid peptide assembly. In addition, the interaction
between liposome samples and amyloid peptide assembly modulated by GO was
investigated. It is achieved that the membrane disruption of amyloid peptide
aggregates can be fine-tuned by tweaking the GO concentration. The findings in this
work provide a better understanding of amyloid peptide and membrane interactions
and how it can be tuned.
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