Neural stem cells: ready for therapeutic applications?

Abstract

Neural stem cells (NSCs) offer a unique and powerful tool for basic research and regenerative medicine. However,
the challenges that scientists face in the comprehension of the biology and physiological function of these cells are
still many. Deciphering NSCs fundamental biological aspects represents indeed a crucial step to control NSCs fate
and functional integration following transplantation, and is essential for a safe and appropriate use of NSCs in
injury/disease conditions. In this review, we focus on the biological properties of NSCs and discuss how these cells
may be exploited to provide effective therapies for neurological disorders. We also review and discuss ongoing
NSC-based clinical trials for these diseases.